I am working on a score with VDL 2.5 Template with Sibelius 6.  All of a sudden the template seems to be reconfigured.  I was using SnareLine (AutoLR) and the keys seem to be configured differently.  I also notice there's an advanced functions key on my MIDI keyboard that sedems to randomly turn off while I'm trying to write the music and seems to mess up everything.

Any help would be greatly appreciated.  Not sure what to do.

Are you sure you have Kontakt Player 2 or Kontakt set as your active device in your playback configuration, with the correct sound selected? What kind of MIDI keyboard is it? The make and model would help a bit.